
Evening Primrose (Oenothera biennis)
Photo: Christian Ferrer · CC BY-SA 4.0
- Digestive
- 3 conditions
- Licensed photo
Overview
Biennial herb growing to 8 in (20 cm). Has red blotches on stem, crinkled lance-shaped leaves, 4-petaled yellow flowers, and elongated seed capsules.
Safety & precautions
Do not take evening primrose oil if suffering from epilepsy.
Educational reference only - not medical advice. Herbs can interact with medications. Consult a qualified healthcare provider before use. Full disclaimer.
Drug interactions
Evidence on evening primrose oil interactions is limited. [1, 2]
- HIV medicines (antiretrovirals)
- A 2017 systematic review found that evening primrose oil significantly raised levels of some antiretrovirals and advised watching for side effects. MSK names lopinavir. [1, 2]
- Blood thinners and antiplatelet drugs
- MSK cites a small human study in which months of GLA from evening primrose oil lengthened bleeding time in most participants, so effects may add up. [1]
- Blood pressure medicines
- MSK notes no reported interactions, but a large population study linked evening primrose oil with higher blood pressure. [1]
How to read this section: each entry is HerbMate's summary of what the cited sources report. Words such as "may", "theoretical" or "in laboratory or animal studies" mean the effect has not been confirmed in people, and "case report" means it was seen in one or a few patients. A medicine that is not listed here has not been shown to be safe with this herb. The numbers in brackets link to the sources at the foot of the page.
Habitat
Native to North America, evening primrose is now commonly found in many temperate zones around the world. It thrives in open areas, especially in dunes and sandy soil. Evening primrose is grown commercially for its seed oil.
Sources
The interaction notes and the statements on this page that name a source were written by HerbMate from these references, which were last checked in October 2026. They are summaries, not medical advice; ask a pharmacist about your own medicines.
Traditionally used for
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Frequently asked questions
What safety cautions apply to Evening Primrose (Oenothera biennis)?
Do not take evening primrose oil if suffering from epilepsy.







