HerbMate
Senna (Cassia senna) plant
Digestive

Senna (Cassia senna)

Photo: Lalithamba from India · CC BY 2.0

  • Digestive
  • 1 condition
  • Licensed photo

Overview

Senna (Senna alexandrina, syn. Cassia senna) is a small shrub about 3 ft (1 m) tall, with yellow, pea-like flowers and pods containing seeds. Senna contains anthraquinone glycosides called sennosides, and MedlinePlus describes it as a stimulant laxative used on a short-term basis to treat constipation.

Traditional uses & properties

Stimulant Laxative: MedlinePlus says senna works by increasing the activity of the intestines and normally causes a bowel movement within 6 to 12 hours.

Safety & precautions

Short-Term Use: MedlinePlus advises not using senna for more than a week without talking to a doctor; frequent or continued use can make the bowel dependent on laxatives. Liver: LiverTox lists senna as a possible rare cause of liver injury, mainly at high doses taken for longer than recommended. Children Under 12: Not advisable. Pregnancy: Consult a professional. Gastrointestinal Sensitivity: May cause cramping and discomfort.

Educational reference only - not medical advice. Herbs can interact with medications. Consult a qualified healthcare provider before use. Full disclaimer.

Drug interactions

Senna is a stimulant laxative sold as an over-the-counter medicine. [1]

Digoxin
A large 2011 case-control study of people with heart failure found that recent sennoside use was associated with a modestly higher risk of digoxin toxicity. [2]
Other medicines taken by mouth
MedlinePlus advises taking certain senna products well apart from other oral medicines, as the label directs, because they may affect how those medicines work. [1]
Mineral oil
MedlinePlus lists mineral oil as a nonprescription product that may interact with senna. [1]

How to read this section: each entry is HerbMate's summary of what the cited sources report. Words such as "may", "theoretical" or "in laboratory or animal studies" mean the effect has not been confirmed in people, and "case report" means it was seen in one or a few patients. A medicine that is not listed here has not been shown to be safe with this herb. The numbers in brackets link to the sources at the foot of the page.

Habitat

Primarily native to tropical Africa, senna is cultivated in many tropical regions. Leaves can be picked before or during flowering; pods are collected fully ripe in autumn.

Sources

The interaction notes and the statements on this page that name a source were written by HerbMate from these references, which were last checked in October 2026. They are summaries, not medical advice; ask a pharmacist about your own medicines.

  1. MedlinePlus Drug Information: Senna
  2. Wang MT, et al. Exposure to sennoside-digoxin interaction and risk of digoxin toxicity. Eur J Heart Fail, 2011 (PubMed 21803754)
  3. LiverTox (NIDDK, NIH): Senna

Traditionally used for

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Frequently asked questions

What is Senna (Cassia senna) traditionally used for?

Traditional sources describe Senna (Cassia senna) as follows: Stimulant Laxative: MedlinePlus says senna works by increasing the activity of the intestines and normally causes a bowel movement within 6 to 12 hours.

What safety cautions apply to Senna (Cassia senna)?

Short-Term Use: MedlinePlus advises not using senna for more than a week without talking to a doctor; frequent or continued use can make the bowel dependent on laxatives. Liver: LiverTox lists senna as a possible rare cause of liver injury, mainly at high doses taken for longer than recommended. Children Under 12: Not advisable. Pregnancy: Consult a professional. Gastrointestinal Sensitivity: May cause cramping and discomfort.