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Guggul (Commiphora mukul) plant
Circulatory

Guggul (Commiphora mukul)

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  • Circulatory
  • 3 conditions
  • Licensed photo

Overview

Guggul is a spiny shrub or tree growing to 6.5 feet with oval, serrated leaves, brownish-red flowers, and red fruits. The gum resin obtained from the bark forms pale yellow to brown 'tears' on the stems. Thriving in dry, semi-arid, and desert environments across much of the Indian subcontinent and the Middle East, it has been valued in Ayurvedic medicine for millennia. Guggul has been used in Ayurvedic medicine for centuries, and it has been studied for raised blood cholesterol; MSK says evidence is lacking for weight loss, studies on cholesterol are mixed, and one study suggests it may raise cholesterol.

Traditional uses & properties

Guggul is promoted for weight loss and high cholesterol; MSK says evidence is lacking for weight loss and studies on cholesterol are mixed. Its fat-soluble steroids, particularly guggulsterones E and Z, are the main active constituents. In Ayurveda, guggul is used for rheumatism and arthritis; MSK says evidence is lacking to support its use for arthritis. It is also used for acne; MSK says evidence is lacking for guggul alone.

Safety & precautions

Avoid if breastfeeding. Because it thins the blood, do not use in persons who bleed easily or during pregnancy. Avoid with hyperthyroid disorders. Medicines: In a small study in healthy volunteers, a single dose of gugulipid lowered blood levels of propranolol and diltiazem, which could make those drugs less effective. Laboratory studies summarized by MSK suggest guggul induces the enzyme CYP3A4, which could lower levels of other medicines processed by it. Ask a pharmacist before combining guggul with prescription drugs.

Educational reference only - not medical advice. Herbs can interact with medications. Consult a qualified healthcare provider before use. Full disclaimer.

Drug interactions

Interaction data is not available for this herb - talk to a pharmacist before combining it with any medication. A blank entry here means we have not documented interactions, not that none exist.

Habitat

Guggul thrives in dry, semi-arid, and desert environments across much of the Indian subcontinent and the Middle East. The gum resin is harvested from the bark.

Sources

The interaction notes and the statements on this page that name a source were written by HerbMate from these references, which were last checked in October 2026. They are summaries, not medical advice; ask a pharmacist about your own medicines.

  1. Dalvi SS, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Physicians India, 1994 (PubMed 7852226)
  2. Memorial Sloan Kettering, About Herbs: Guggul

Traditionally used for

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Frequently asked questions

What is Guggul (Commiphora mukul) traditionally used for?

Traditional sources describe Guggul (Commiphora mukul) as follows: Guggul is promoted for weight loss and high cholesterol; MSK says evidence is lacking for weight loss and studies on cholesterol are mixed. Its fat-soluble steroids, particularly guggulsterones E and Z, are the main active constituents. In Ayurveda, guggul is used for rheumatism and arthritis; MSK says evidence is lacking to support its use for arthritis. It is also used for acne; MSK says evidence is lacking for guggul alone.

What safety cautions apply to Guggul (Commiphora mukul)?

Avoid if breastfeeding. Because it thins the blood, do not use in persons who bleed easily or during pregnancy. Avoid with hyperthyroid disorders. Medicines: In a small study in healthy volunteers, a single dose of gugulipid lowered blood levels of propranolol and diltiazem, which could make those drugs less effective. Laboratory studies summarized by MSK suggest guggul induces the enzyme CYP3A4, which could lower levels of other medicines processed by it. Ask a pharmacist before combining guggul with prescription drugs.