
Peppermint (Mentha x piperita)
Photo: Jamain · CC BY-SA 3.0
- Digestive
- 2 conditions
- Licensed photo
Overview
Peppermint (Mentha × piperita) is a fast-growing, square-stemmed herb (commonly about 32 in / 80 cm tall), with lanceolate, serrated leaves and purplish flowers. A natural hybrid of watermint and spearmint, peppermint is renowned for its cooling, aromatic flavor, and mint plants have been used for digestive disorders since ancient Greece, Rome and Egypt. NCCIH says a small amount of research suggests enteric-coated peppermint oil capsules may improve IBS symptoms in adults, but there is not enough evidence to know whether peppermint leaf helps any condition.
Traditional uses & properties
Antispasmodic & Carminative: Traditionally used for gastrointestinal ailments; NCCIH says enteric-coated peppermint oil capsules may improve IBS symptoms in adults, but there is no evidence that peppermint oil alone helps indigestion. Headache: NCCIH says limited evidence suggests peppermint oil applied to the skin might relieve tension headaches. Inhaled oil: NCCIH warns that peppermint oil should not be applied to the face of infants or young children because the menthol may affect their breathing.
Amounts reported by sources
These are the amounts the named source reports, such as the doses used in studies or the directions on a product label. They are not a dosage recommendation from HerbMate. Products differ in strength and safe use depends on the person, so ask a pharmacist or clinician before taking any herb.
NCCIH says a small amount of research suggests enteric-coated peppermint oil capsules may improve IBS symptoms in adults.
Safety & precautions
Children under 5: Avoid giving peppermint tea in strong doses; can irritate sensitive mucous membranes. GERD & Heartburn: May aggravate reflux by relaxing the lower esophageal sphincter. Essential Oil Internally: Use only under professional supervision; not suitable for children under 12.
Educational reference only - not medical advice. Herbs can interact with medications. Consult a qualified healthcare provider before use. Full disclaimer.
Drug interactions
Most concern involves peppermint oil, not tea, and its effect on the enzyme CYP3A4. [1, 2]
- Felodipine
- In a 2002 crossover study in healthy volunteers, peppermint oil raised felodipine blood levels. The authors proposed CYP3A4 inhibition as a possible cause but said this needs more study. [1, 2]
- Cyclosporine
- Peppermint oil increased cyclosporine absorption in rats, yet MSK also describes a kidney transplant patient whose cyclosporine level fell after drinking an herbal tea that included peppermint. [2]
- Medicines broken down by liver enzymes
- Laboratory studies show peppermint oil and its constituents inhibit several CYP enzymes, including CYP3A4. [1, 2]
- Topical 5 fluorouracil
- Applied to the skin, peppermint oil can increase absorption of this cream. [2]
How to read this section: each entry is HerbMate's summary of what the cited sources report. Words such as "may", "theoretical" or "in laboratory or animal studies" mean the effect has not been confirmed in people, and "case report" means it was seen in one or a few patients. A medicine that is not listed here has not been shown to be safe with this herb. The numbers in brackets link to the sources at the foot of the page.
Habitat
Grown widely in Europe, Asia, and North America as a culinary and medicinal plant, peppermint is propagated from seed or runners in spring, and harvested just before flowering in summer. The aerial parts are used for infusions and distilled to yield essential oil.
Sources
The interaction notes and the statements on this page that name a source were written by HerbMate from these references, which were last checked in October 2026. They are summaries, not medical advice; ask a pharmacist about your own medicines.
Traditionally used for
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Frequently asked questions
What is Peppermint (Mentha x piperita) traditionally used for?
Traditional sources describe Peppermint (Mentha x piperita) as follows: Antispasmodic & Carminative: Traditionally used for gastrointestinal ailments; NCCIH says enteric-coated peppermint oil capsules may improve IBS symptoms in adults, but there is no evidence that peppermint oil alone helps indigestion. Headache: NCCIH says limited evidence suggests peppermint oil applied to the skin might relieve tension headaches. Inhaled oil: NCCIH warns that peppermint oil should not be applied to the face of infants or young children because the menthol may affect their breathing.
What amounts do sources report for Peppermint (Mentha x piperita)?
These are the amounts the named source reports, such as the doses used in studies or the directions on a product label. They are not a dosage recommendation from HerbMate. Products differ in strength and safe use depends on the person, so ask a pharmacist or clinician before taking any herb. Irritable Bowel Syndrome: NCCIH says a small amount of research suggests enteric-coated peppermint oil capsules may improve IBS symptoms in adults.
What safety cautions apply to Peppermint (Mentha x piperita)?
Children under 5: Avoid giving peppermint tea in strong doses; can irritate sensitive mucous membranes. GERD & Heartburn: May aggravate reflux by relaxing the lower esophageal sphincter. Essential Oil Internally: Use only under professional supervision; not suitable for children under 12.






